Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms

Surgery is a crucial intervention and provides the best chance of cure for patients with colorectal cancer. Experimental clinical evidence, however, suggests that paradoxically surgery itself may precipitate or accelerate tumor recurrence and/or liver metastasis development. This review addresses various aspects surgery-induced formation sheds light on role inflammation as potential trigger Understanding these mechanisms provide new perioperative interventions to improve treatment outcomes, such could transform timeframe from facilitator metastatic progression window opportunity reduce risk Ultimately, this can potentially long-term survival rates quality life in